As these differences are more common at the genus level, we extracted the strains with abundance differences at this level for ANOVA and found that r-irisin reversed the decrease of the abundance of Odoribacter and the increase of Eisenbergiella and Dubosiellad in PCOS mice caused by DHEA and HFD exposure at this level (Figure 5C). Here, FNDC5 is linked to polycystic ovary syndrome.