FXN and Friedreich ataxia: Our study also sheds light on the specific downregulation of Tug1 in the cerebellum, which is crucial given the extensive cerebellar damage observed in Friedreich's ataxia.32,33 The early detection of Tug1 downregulation in the cerebellum and its strong linear correlation with Fxn levels provide compelling evidence for Tug1’s importance in understanding the regional specificity of neuronal damage in Friedreich's ataxia.50-53 Ultimately, our work delves into the downstream target genes of Tug1, which include genes implicated in cellular processes disrupted in Friedreich's ataxia.