VAPB and amyotrophic lateral sclerosis: It is the first time that changes to paw placement have been reported in an animal model of ALS and may indicate sensory dysfunction, such as pain sensitivity could be recapitulated in the mutant VapB rats.40 Fifty per cent of all patients with ALS suffer extramotor dysfunction, mainly relating to the sensory and autonomic systems,41 and pain is reported by the majority of patients with ALS8.2