Likewise, the common rs641738 close to MBOAT7 has been pointed out as a modifier of the susceptibility to develop HCC even in the absence of cirrhosis as a consequence of its ability to induce giant lipid droplets (LDs) into the hepatocytes and other rare loss-of-function variants in the same gene have been found enriched in patients with MASLD-HCC (15). The gene discussed is MBOAT7; the disease is hepatocellular carcinoma.