Genetic variants which predispose to HCC are those in genes related to hepatic lipid handling including the Patatin-like phospholipase domain containing 3 (PNPLA3), the Transmembrane 6 superfamily member 2 (TM6SF2) and Membrane bound-o-acyltransferase domain-containing 7 (MBOAT7), widely reported to be responsible for fatty loading of the liver (10). The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.