In model 1, without any adjustment of confounding factors, we found that high level of HO-1 correlated with reduced incidence of hyperlipidemia (OR, 0.46; 95% CI, 0.31–0.70, p = 0.0003), while no significant association between hyperlipidemia and low or middle level of HO-1. The gene discussed is HMOX1; the disease is hyperlipidemia.