Interestingly, it has recently shown that CD147 may contribute to fibroblast activation induced by SARS-CoV-2 through a TGF-β1-CD147 self-sustaining network (Wu et al., 2022), Furthermore, many COVID-19 patients exhibit an increased frequency of pathological fibroblasts (pFBs) (Melms et al., 2021). This evidence concerns the gene BSG and COVID-19.