MTOR and neoplasm: A novel vitamin D3 analog, Gemini-23-yne-26,27-hexafluoro-D3, not only increased the expression of PTEN and caused the dephosphorylation of Akt, Ark target proteins, and mTOR, but also decreased the phosphorylation of its downstream effectors, S6Ks, and eukaryotic translation initiation factor 4E-binding protein 1, thereby suppressing protein synthesis and tumor proliferation (44) (Figures 1E1–E4).