According to Martin Reindl et al.'s prospective case study, individuals without CKD3 and community residents also showed a correlation between FGF23 levels and cardiovascular mortality. Patients with acute or chronic heart failure as well as those with coronary artery disease (CAD) have shown that FGF23 is a potent predictor of cardiovascular mortality [11]. This evidence concerns the gene FGF23 and congestive heart failure.