Li et al., 2022 demonstrated that poly (lactic acid)-glycolic acid copolymerization-nanoparticles (SOD-PLGA-NPs) possess potent free radical scavenging capabilities, reducing cerebral infarct size in mice post-IS and ameliorating neurological deficits resulting from cerebral ischemia in the MCAO mouse model. This evidence concerns the gene SOD1 and cerebral infarction.