Using APP/PS1 mice as subjects, researchers found that the monoterpene glycoside paeoniflorin (PF) improved cognitive performance and downregulated the levels of Fe2+, MAD, and ROS in brain tissue, which reduced oxidative damage and thus alleviated the neurological damage in AD mice (Zhang and Wei, 2020; Zhai et al., 2023). This evidence concerns the gene APP and Alzheimer disease.