TP53 and ischemic stroke: In a study conducted in 2017, Yan et al., 2022 discovered that the small molecule protein-protein interaction (PPI) inhibitor K-181 could suppress p53 transcription and ameliorate neurological impairments post-ischemic stroke (IS) by increasing the expression of the p53 repressor Mdmx, consequently inhibiting p53 transcription in the brains of mice following IS.