APP and Alzheimer disease: In addition, Yael Avramovich-Tirosh et al. reported that the synthetic iron chelator [5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline] (M-30), which permeates the BBB and reduces cellular APP and Aβ production levels, was shown to alleviate the intellectual disability in mice after AD in an in vivo animal model (Avramovich-Tirosh et al., 2007; Zhang et al., 2022).