There are interactions described in the diffusion profile between V2R and the process of cell proliferation, which is itself dysregulated in ADPKD by the polycystins (Grimm et al., 2006), the renin-angiotensin-aldosterone system, dysfunction of which is both a downstream consequence of, and direct contributor to ADPKD (Hian et al., 2016), and components of the G protein-coupled receptor signalosome, which regulate ADPKD-associated proteins such as CFTR and EGFR (Hama and Park, 2016; Sussman et al., 2020). Here, AVPR2 is linked to autosomal dominant polycystic kidney disease.