VEGF signalling has previously been linked with ADPKD pathophysiology (Tao et al., 2007), and herein the diffusion profile suggests this could be mediated in part via the regulation of apoptosis, which is itself a key process known to be dysregulated in the disease state (Zhou and Li, 2015). The gene discussed is VEGFA; the disease is autosomal dominant polycystic kidney disease.