Loss of polycystin-1 is associated with an increase in HDAC6 (Liu et al., 2012) and SIRT2 (Zhou et al., 2014) expression, and a decrease in acetylated α-tubulin (Zhou et al., 2014), while inhibition of either deacetylase has been shown to augment α-tubulin acetylation levels and ameliorate ADPKD-relevant phenotypes (Zhou et al., 2014; Cebotaru et al., 2016; Yanda et al., 2017). This evidence concerns the gene HDAC6 and autosomal dominant polycystic kidney disease.