The diffusion profile makes a direct connection between these microtubule proteins and the ADPKD-associated proteins EGFR and CFTR, trafficking of which has indeed previously been linked to the state of the microtubule network (Morris et al., 1998; Liu et al., 2012), and may explain in part the downstream effects of mebendazole-induced microtubule destabilisation on ADPKD-relevant networks. Here, EGFR is linked to autosomal dominant polycystic kidney disease.