PKD1 and Renal cyst: On PND75, kidney volume in Pkd1 wildtype mice was increased by an average of 47% compared with pre-dosing values taken on PND41, whereas in the same timeframe, kidney volume in vehicle treated Pkd1 KO mice increased by an average of 291%, consistent with the development of enlarged cystic kidneys by the midpoint in this study (Figure 3F).