PRMT5 regulates gene expression via the dimethylation of arginine residues in histone and non-histone protein targets, and has been associated with the direct control of both NF-κB (Wei et al., 2013) and PPAR (Huang et al., 2018) transcriptional regulation, which align with the top consensus pathways identified here in the cloperastine-ADPKD gene expression overlaps. Here, PRMT5 is linked to autosomal dominant polycystic kidney disease.