GLP1R and diabetes mellitus: However, recent randomised controlled trials (RCTs) have demonstrated the efficacy of some GLP-1 RAs for weight reduction in adults even without diabetes, leading to semaglutide and liraglutide approval as adjuncts to a calorie-restricted diet and exercise for weight management.2, 3, 4 Tirzepatide, a newer dual receptor agonist, has also been demonstrated to induce greater weight reductions,5 and has recently been approved for patients without diabetes in some countries.6