Rømer reported that the glycosylation was induced by changing the levels of ZIP9 and Zn2+ [8].C1GALT1, a key regulated enzyme of O-glycosylation, plays an important role in the cancer development, metastasis and prognosis [19], such as breast cancer [20], bladder cancer [21], neuroblastoma [22] and endometrial cancer [23]. This evidence concerns the gene C1GALT1 and breast cancer.