From the analysis of in vivo data, it is possible to infer that HBL‐4 degrader had great antitumor effects in MV4‐11 tumor xenograft model, through the degradation of PLK1 and BRD4, in a well‐tolerated way, surpassing the effects observed with the use of TLM inhibitor.136. Here, BRD4 is linked to neoplasm.