Although its role is not yet completely clear in cancer development, since recent evidence indicates that BRD4 relevance in cancer goes beyond its role in transcription regulation, it is known that the BRD4 protein is often found overexpressed and abnormally activated in several types of cancer, including AML, ALL, and CML, and has therefore been extensively studied as a promising target involved in tumorigenesis and tumor progression.120, 121. This evidence concerns the gene BRD4 and acute myeloid leukemia.