PROTAC YX‐2‐107 when tested in ALL‐Ph+ cell lines (Ph1 BV173 and SUP‐B13 cells) selectively degraded CDK6 (with a degradation constant of ∼4 nM) and inhibited the G1‐S transition, FOXM1 expression, Rb phosphorylation, and cell proliferation.148, 153. This evidence concerns the gene CDK6 and acute lymphoblastic leukemia.