When tested on both RS4;11 and MV4;11 leukemia cell lines with WT p53, PROTACs MD‐222 and MD‐224 rapidly induced CRBN‐dependent degradation of MDM2 at concentrations as low as 1 nM, with MD‐224 the most powerful of all.164, 165. The gene discussed is TP53; the disease is leukemia.