By promoting the degradation of BRD4, both c‐Myc and ANP32B were downregulated by this degrader, resulting in cytotoxic effects (inhibition of cell proliferation, induction of apoptosis, and cell cycle arrest at G1) at low concentrations, in several representative AML cell lines of different sub‐molecular types.132. This evidence concerns the gene MYC and acute myeloid leukemia.