The FGFR3::TACC3 fusion has been described in a variety of gliomas, including glioblastomas, and can produce a variety of morphologies and outcomes.13,14 To the best of our knowledge, FGFR3::TACC3 has not previously been associated with epithelial differentiation in gliomas, although it does occur in carcinomas.15 This evidence concerns the gene TACC3 and carcinoma.