RAG1 and Hyperglycemia: This interaction indicated that, while in wt mice B. uniformis reduced both, fasting glycemia and the AUC, it failed to alleviate hyperglycemia and oral glucose intolerance in Rag1-/- mice (Fig. 3D and E), overall suggesting that adaptive immunity is required for the B. uniformis-mediated effects on glucose homeostasis but not for limiting fat depots.