Many important PD risk genes are involved in endosomal (LRRK2, SNCA) and lysosomal (GBA, TMEM175, CTSB) function, mitophagy (PINK1, PARK2), autophagy (SNCA, KAT8), RNA processing (TARDBP), and antigen presenting (HLA-DRB6, HLA-DQA1) [95]. Here, SNCA is linked to Parkinson disease.