MS4A4E and Alzheimer disease: Furthermore, Lopatko Lindman et al. reported an association between AD, HSV-1, and a risk score which was calculated from the presence of mutations in nine AD risk genes (ABCA7, BIN1, CD33, CLU, CR1, EPHA1, MS4A4E, NECTIN2, and PICALM) (OR 2.35, 95% CI: 1.21–4.56, P = 0.01) [125].