Mechanistically, radiotherapy-induced low COMMD10 expression inhibits ubiquitin degradation of HIF1A, inducing copper accumulation and promoting nuclear translocation of HIF1A to induce transcription of ceruloplasmin (CP) and SLC7A11, thus inhibiting ferroptosis in hepatocellular carcinoma cells and tumor-bearing mice [269]. This evidence concerns the gene COMMD10 and hepatocellular carcinoma.