While monocyte to macrophage differentiation-associated (MMD) activity can engage with ACSL4 and membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), enhancing the influx of arachidonic acid into phosphatidylinositol and augmenting the sensitivity of OVCAR-8 and 786-O cells to ferroptosis, the broader impact of MMD on ferroptosis in other cancer cell lines, non-cancerous environments, and in vivo settings remains unexplored [38]. Here, ACSL4 is linked to cancer.