For instance, the BRCA1/BRCA2-containing complex subunit 3 (BRCC3; also known as BRCC36) deubiquitinates HMGCR, a process dependent on deubiquitinating enzyme (DUB) activity, thereby inhibiting ferroptosis in human hepatocellular carcinoma cells while promoting cellular pyroptosis [421]. Here, BRCC3 is linked to hepatocellular carcinoma.