Third, environmental pollutants such as acrolein and arsenic, which pose a high risk for type 2 diabetes mellitus, can induce ferroptosis and disrupt insulin secretion via the ER stress-related eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3; also known as PERK) pathway in mouse pancreatic β-cell MIN6 cells [251]. This evidence concerns the gene EIF2AK3 and type 2 diabetes mellitus.