Similarly, liver-specific knockout of Gpx4 accelerates diethylnitrosamine-induced hepatocellular carcinoma by releasing high-mobility group box 1 (HMGB1), recruiting myeloid-derived suppressor cells (MDSCs), and upregulating the checkpoint protein CD274 (also known as PD-L1) [171]. This evidence concerns the gene GPX4 and hepatocellular carcinoma.