YEATS domain-containing 4 (YEATS4; also known as GAS41) interacts with NFE2 like BZIP transcription factor 2 (NFE2L2, also known as NRF2) and modulates its transcriptional activity through H3K27 acetylation (H3K27-ac), thereby selectively activating the transcription of NFE2L2 target genes to suppress ferroptosis in human melanoma and lung cancer cells [120]. The gene discussed is NFE2L2; the disease is melanoma.