HIF1A and hepatocellular carcinoma: Mechanistically, radiotherapy-induced low COMMD10 expression inhibits ubiquitin degradation of HIF1A, inducing copper accumulation and promoting nuclear translocation of HIF1A to induce transcription of ceruloplasmin (CP) and SLC7A11, thus inhibiting ferroptosis in hepatocellular carcinoma cells and tumor-bearing mice [269].