HGH1 and breast cancer: In addition, proteomics, co-immunoprecipitation (co-IP), and Ribosome sequencing (Ribo-Seq) were used to explore the biological role of HGH1 in BC.<h4>Results</h4>As the main m<sup>5</sup>C methylation molecule, NSUN2 is abnormally overexpressed in BC and increases the overall level of RNA m<sup>5</sup>C.