Indeed, we observed consistent results on 5 genes: TNFSF13B, FOXP1, TCF21, BST2 and STRA6 [14–20].Taken together, despite little overlap with previously characterized genes, the characterized methylated genes in endometriosis were consistent with the reported expression changes in endometriosis(Table 3).RT-PCR results showed that ER1,STAR6 and PEMT were significantly downregulated in ectopic tissues, and BST2,TCF21 and FOXP1 were significantly upregulated in ectopic tissues (Fig. 9 ). The gene discussed is PEMT; the disease is endometriosis.