Overexpression of β-catenin in SLC1A5-knockdown HCC cell lines could augment Vimentin and N-cadherin expression, suppress E-cadherin expression, and increase the migration and drug resistance.<h4>Conclusions</h4>Elevated SLC1A5 was linked to TACE resistance and survival shortening in HCC patients. Here, SLC1A5 is linked to hepatocellular carcinoma.