Additionalmechanisms linking pesticide exposure to tumor metastasis includedepletion of antitumor proteins, such as interleukin 12, and augmentedexpression of protumoral molecules, such as CLTA-4 and TGF-β1.76 These mechanisms are not reported in unexposedBC women and are suggested as a worse prognosis signature linked topesticide exposure. The gene discussed is TGFB1; the disease is neoplasm.