CD8A and cancer: Killing of ovalbumin (OVA)-expressing cancer cells by antigen-specific CD8+ T (OT-I) cells, major histocompatibility complex class I (MHC class I) exposed to the cell membrane and antigen presentation in OVA-expressing cancer cells (both at baseline and after interferon-γ (IFNγ) stimulation) were all not affected by Cda deletion (Extended Data Fig. 4m–o).