DIAPH2 and neoplasm: As mentioned in Introduction of our manuscript and considering the fact that DIAPH2 gene mutations were present in approximately a few percent of LSCCs and that high expression of DIAPH2 was associated with advanced tumor stage, lymph node metastasis and poor overall survival, it should be stressed that our results may have the practical aspect and may allow the creation, after confirmation in other studies, of an early marker of LSCC which can be useful in the diagnosis of LSCC at an early stage in some risk groups, such as smokers.