While evidences suggest an asymmetric barrier between the seeding of 3R and 4R tau [50, 51], however, unlike progressive supranuclear palsy (PSP) and Pick’s disease (PiD) whose NFTs assembly visibly favours 4R and 3R tau respectively [52], AD tauopathy does not display an established preference. The gene discussed is MAPT; the disease is progressive supranuclear palsy.