Already Fujisawa et al. [32] postulated on a basis of seven patients that germinoma of the hypothalamo-neurohypophyseal axis arise from the neurohypophysis and a theory by Tan [4] was that anterior midline structures are highly active in hormone production and concentration in factors like GnRH, potentially playing a role in tumorigenesis. Here, GNRH1 is linked to germinoma.