In addition, the 4 VUS identified in this study (CFTR: rs1800120, TBC1D24: rs754558646, HTT: rs779780620, and FDX2: rs897162037) were found to coexist with several other P/LP variants or VUS in genes associated with cardiovascular/metabolic diseases or CoQ deficiency. This evidence concerns the gene CFTR and Other metabolic disease.