Our study illustrated that diagnostic value of serum copeptin for identification of DN by using the ROC curve analysis where the best cut off value was 461.2 ng/mL with 91.5% sensitivity and 82.3% specificity and for UPb, ROC curve analysis indicated the best cut off value was 0.23 ng/mg creat with sensitivity of 88.5% and sensitivity of 81.2% specificity (Fig. 4). This evidence concerns the gene AVP and liver dysplastic nodule.