Aljorani et al.41 conducted a study to evaluate biomarkers including KIM-1 to help in early prediction of DN among type 2 diabetic patients, they showed a significant increase in serum and urinary levels of KIM-1 and its negative correlation with eGFR which was highly suggestive that KIM-1 could be sensitive and specific biomarker of DN among type 2 diabetic patients. Here, HAVCR1 is linked to liver dysplastic nodule.