Interestingly, most of these effects were demonstrated only in male, but not in female mice.<h4>Conclusion</h4>These findings suggest that BCAAs per se can acutely impair glucose homeostasis and insulin sensitivity, thus offering an explanation for how they may disrupt glucose metabolism in the long-term as observed in obesity and diabetes. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.