Regulation of RNA Pol III and thus Y RNA expression by ADAR1 provides also an unexpected piece to the puzzle of onset of autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome in which the role of Ro60 and ADAR has been proposed (Boccitto and Wolin 2019; Dolcino et al. 2019; Quinones-Valdez et al. 2019; Muro et al. 2020). The gene discussed is RO60; the disease is Sjogren syndrome.