MIF is required for sustained inflammatory activation of both innate and adaptive immune cells in experimental autoimmune encephalitis (EAE), a rodent model of autoimmune demyelination.40 41 We observed higher MIF levels in NMOSD compared with MS, in agreement with a prior study comparing conventional MS with the optic-spinal variant, which is now thought to be synonymous with NMOSD.28 This evidence concerns the gene MIF and myeloid sarcoma.