miR-153 promotes cellular invasion in the progression of CRC, and its interaction with small nucleolar RNA host gene 17 (SNHG17)-collagen type XI alpha 1 (COL11A1)/insulin-like growth factor-binding protein 3 (IGFBP3)/krüppel-like factor 6 (KLF6) or with taurine upregulated gene 1 (TUG1)-death-associated protein kinase 1 (DAPK1)/aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)/kallikrein-related peptidase 3 (KLK3)/phospholipase D1 (PLD1)/SMAD family member 2 (SMAD2) may play a role in early-stage colon adenocarcinoma [41]. Here, SMAD2 is linked to colon adenocarcinoma.