CDH1 and esophageal squamous cell carcinoma: IDH3β is considered a novel APC/C-CDH1 substrate and an important regulator of the cell cycle that can promote cell proliferation in ESCC, and the overexpression of IDH3β is often correlated with poor prognosis in ESCC [52]; this correlation is consistent with the high HR of IDH3β in our study (HR=2.29).