CSF2 and AIDS: While it seems plausible that shared traits underlie emergence of pathogenic species, it is also likely that finer differences will emerge within the pathogens given that some species (C. neoformans, C. deneoformans, C. bacillisporus, and C. tetragattii) predominantly infect HIV/AIDS patients, whereas others (C. gattii and C. deuterogattii) infect largely non-HIV/AIDS patients, such as those with autoantibodies to the cytokine GM-CSF [113–116].