We also assessed the hCoV-229E virus RNA levels in wildtype or 14-3-3η KD Huh7 cells, and we found that Huh7 cells expressing Myc-14-3-3ηΔαI were slightly more permissive to the hCoV-229E infection, as the vRNA levels at both 6 and 12 hours post-hCoV-229E infections were the highest among all (Figs 4C and S4C). The gene discussed is MYC; the disease is infection.