The ability of EBV-specific T cell responses to target antigens from the central nervous system (CNS) was also investigated.<h4>Methods</h4>Untreated persons with relapsing-remitting MS, POST-IM individuals and HC were, as far as possible, matched for gender, age and HLA-DRB1*15:01. This evidence concerns the gene HLA-DRB1 and relapsing-remitting multiple sclerosis.