Finally, we analyzed the observed sensitivity of cancer cell lines to either SHP2 deletion or SHP2 inhibition (23) and found that the two SHP2-independent cell lines with strong sensitivity to SHP099 treatment, pancreatic cancer cell line T3M4_PANCREAS (KRASQ61H) and melanoma cell line WM115_SKIN (BRAFV600E), are highly dependent on autophagy (ATG4B) for survival (DepMap Portal; https://depmap.org/portal) (Supplemental Figure 3E). Here, ATG4B is linked to cancer.