CASP3 and Hyperglycemia: This work also revealed that CRISPR-mediated gene editing of Ripk3 protects NIT-1 β-cells from TNFα-induced cell death independent of caspase 3/7 activation in vitro, and that RIPK3 knockout mice are protected from STZ-induced hyperglycemia in vivo (Contreras et al. 2022).