RIPK1 and type 1 diabetes mellitus: Human Pancreas Analysis Program (HPAP) data indicate that Ripk1 gene expression is increased 2.7-fold in β-cells from individuals with T1D compared to those without diabetes (Kaestner et al. 2019), and several studies have investigated the role of RIPK1 kinase function in β-cell cytotoxicity using small molecule RIPK1 kinase inhibitors.