Human Pancreas Analysis Program (HPAP) data indicate that Ripk3 gene expression is increased 2.2-fold in β-cells from individuals with T1D compared to those without (Kaestner et al. 2019), and recent studies have begun to decipher the roles of RIPK3 in β-cell inflammation and cell death signaling. Here, RIPK3 is linked to type 1 diabetes mellitus.