M1 macrophages secrete many cytokines, including interleukin 1-beta (IL-1β), tumor necrosis factor alpha and beta (TNF-α and TNF-β), and interleukin 6 (IL-6), and are regarded as anti-tumor or pro-inflammatory, while M2 are considered as pro-tumor or anti-inflammatory [15]. Here, IL1B is linked to neoplasm.