To sum up, the aforementioned data and results disclosed that lncRNA HOXC-AS3 binding to KDM5B repressed TRIM37-mediated KDM5B ubiquitination and upregulated KDM5B protein levels, ultimately accelerating proliferation of CC cells (Fig. 8), and this work offers an innovative insight into how lncRNA HOXC-AS3 knockdown can play a tumor-suppressive role in the progression of CC and a promising therapeutic approach against CC. This evidence concerns the gene KDM5B and neoplasm.