During analysis of recurrently dysregulated differentially expressed genes (DEGs) in sepsis, we found that Mir22hg, a long non-coding RNA implicated in ferroptosis, was significantly up-regulated in mouse sepsis models, but whether mir22hg can participate in the progression of sepsis by mediating ferritinophagy-mediated ferroptosis is unclear. Here, MIR22HG is linked to Sepsis.