We found that up-regulated genes were associated with complement and coagulation cascades, IL − 17 signaling pathway, PI3K-Akt signaling pathway, and bile secretion, while down-regulated genes were associated with African trypanosomiasis, malaria, neuro-related signaling (Neuroactive ligand-receptor interaction and Axon guidance), and metabolism-related signaling (Fatty acid elongation). Here, AKT1 is linked to human African trypanosomiasis.