Besides those as described above, we also found a vital role of S100A11 localized on the inner membrane with the complex of desmosome proteins, where S100A11 regulates the expression level of DSG1, a component protein of desmosome, by which S100A11 activates the TCF pathway via promoting nuclear translocation of γ-catenin from the desmosome, eventually leading to upregulation of colorectal cancer aggressiveness caused by proliferation and migration advantages. Here, DSG1 is linked to colorectal cancer.