This macrophage influx was further increased at 8 weeks of infection, where PDL1+ PDL2+ macrophages reached 85% of total macrophages; interestingly, other macrophage populations (i.e., double negative and PDL1 single positive) were also found, which suggested a steady infiltration of macrophages (Fig. 3d). This evidence concerns the gene PDCD1LG2 and infection.