NLRP3 and asthma: It is thought that NLRP3 largely contributes to chronic Type 1 (Th1-mediated) and Type 3 (Th17-mediated) inflammatory diseases; however, NLRP3 also promotes Th2 polarization [32] as well as Th2-mediated disease such as asthma [33], showing that NLRP3 activation regulates diverse types of immunity, displaying a high plasticity which we are far from fully understanding.