Accordingly, T. crassiceps infection strongly evokes prostaglandin E2 (PGE2) in AAMs [46], which facilitate host colonization [47], and it was recently shown that PGE2 can activate NLRP3 in peritoneal macrophages during Staphylococcus infection [48]. Here, NLRP3 is linked to staphylococcus aureus infection.