When both WT and NLRP3−/− mice were infected with T. crassiceps, NLRP3−/− mice showed a greater resistance than their WT counterparts (Fig. 2), in line with findings reported for nematode experimental infections where worm burdens of Trichuris muris [18], and Nippostrongylus brasiliensis [19] were lower in NLRP3−/− mice. This evidence concerns the gene NLRP3 and infection.