Prior to infection, we observed that NLRP3−/− mice presented a significant decrease in resident macrophages and eosinophils (Fig. 1a), key innate cells in helminthic infections, showing that NLRP3 is somehow required to collaborate in either cell maturation or in driving myeloid cells influx into peritoneum under homeostatic conditions. This evidence concerns the gene NLRP3 and infection.