Since numerous studies have documented aberrant expression of CDK1 in various tumors, linking it to poor patient prognosis (Piao et al. 2019; Li et al. 2020; Du et al. 2023; Han et al. 2023), analyzing the impact of SRSF9 on S phase transition via CDK1 in GBM cells will deepen our molecular insights. The gene discussed is SRSF9; the disease is glioblastoma.