Next, using survival outcomes and survival time as dependent variables, single and multifactorial Cox regression analyses were performed on these three core genes (NR1I2, CDK1 and CHEK1), Coef correlation coefficients of the Cox risk model for the key genes were computed, and the expression values of NR1I2, CDK1, and CHEK1 in hepatocellular carcinoma patients in the TCGA‐LIHC cohort were included to compute the risk scores of the core genes, and to construct the risk‐scoring system for the combination of the three genes. Here, CHEK1 is linked to hepatocellular carcinoma.