ADRB2 and obesity due to melanocortin 4 receptor deficiency: No statistically significant results were observed with <i>Peroxisome Proliferator-Activated Receptor Gama</i> and <i>ADRB2</i> polymorphisms.<h4>Discussion/conclusion</h4>This study revealed that <i>SIRT1</i> rs7895833 and rs1467568 are potential biomarkers for severe obesity susceptibility and the development of unbalanced metabolic status in obesity, respectively.