No statistically significant results were observed with <i>Peroxisome Proliferator-Activated Receptor Gama</i> and <i>ADRB2</i> polymorphisms.<h4>Discussion/conclusion</h4>This study revealed that <i>SIRT1</i> rs7895833 and rs1467568 are potential biomarkers for severe obesity susceptibility and the development of unbalanced metabolic status in obesity, respectively. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.