Also high blood levels of the systemic vasoconstrictor ET-1 are associated with the lung cancer development [20] and poor survival of NSCLC patients—corresponding pahomechanisms are detailed in the literature including increased oxidative stress and cytosolic Ca2+ as well as promoted NSCLC cell proliferation in EGFR- and HER2-dependent manner [21]. Here, EDN1 is linked to lung cancer.