High tumor CD8+ T cell infiltration was associated with lower peripheral lymphocyte number, lower serum CRP expression, smaller tumor size, and better tumor pathology (<i>p</i> = 0.012, <i>p</i> = 0.040, <i>p</i> = 0.012, and <i>p</i> = 0.029, respectively).<h4>Conclusion</h4>Increased numbers of peripheral lymphocytes, CD33+ cells, CD4+ TILs, and CD8+ TILs were significantly associated with OS in newly diagnosed stage III/IV NSCLC patients, which were positively associated with several basic clinical factors. This evidence concerns the gene CD8A and neoplasm.