This study shows the importance of asprosin in the vascular inflammation of hypertension.<h4>Methods</h4>Primary vascular smooth muscle cells (VSMCs) were obtained from the aorta of animals, including spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), NLRP3<sup>-/-</sup> and wild-type mice. Here, NLRP3 is linked to hypertensive disorder.