NOS2 and breast carcinoma: In MCF7 breast cancer cells, the inhibitory effect of statins is mediated by suppressing arginase activity, reducing the utilization of L-arginine as a polyamine precursor, and simultaneously inducing nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) (Kotamraju et al., 2007).The statins may reduce the risk of HCC is related to increased NADPH formation, which serves as a coenzyme for NOS, leading to enhanced NO production (Erbas et al., 2015).