5-FU significantly increased the iNOS expression to 0.1687 +/− 0.01968 (p < 0.05, vs. control group), and the concentration of nitric oxide to 213 +/− 30.2 mmol/L (p < 0.05, vs. control group) in human liver carcinoma Bel7402 cell line (Jiang et al., 2002). The gene discussed is NOS2; the disease is hepatocellular carcinoma.